Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a translocation that creates the chimeric transcription factor PAX3-FOXO1 (P3F), which assembles de novo super enhancers to drive high levels of transcription of other core regulatory transcription factors (CRTFs).P3F recruits co-regulatory factors to super enhancers such as BRD4, which recogni
Phylogeny of diving beetles reveals a coevolutionary arms race between the sexes.
BACKGROUND: Darwin illustrated his sexual selection theory with male and female morphology of diving beetles, but maintained a cooperative view of their interaction.Present theory suggests that instead sexual conflict should be a widespread evolutionary force driving both intersexual Oven coevolutionary arms races and speciation.METHODOLOGY/PRINCIP
The Various Ways in Which Birds Blink
There has, to date, been no systematic study of the various ways in which birds blink.Digital video recordings were made, and studied using still frames, of 524 bird species, mainly in zoos but also in the wild.Videos on 106 species from various sites on the internet were studied, some of which we had also videoed, giving a total of 591 (out of a p
Genetic Polymorphism Effect on Warfarin–Rifampin Interaction: A Case Report and Review of Literature
Muhammad Salem,1 Islam Eljilany,2 Ahmed El-Bardissy,1 Hazem Elewa2,3 1Department of Pharmacy, Hamad General Hospital, Doha, Qatar; 2College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 3Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, QatarCorrespondence: Ahmed El-BardissyDepartment of Pharmacy, Hamad Genera